7SUY
Carbonic Anhydrase IX-mimic Complexed with 2-((3-Aminopropyl)(phenethyl)amino)-N-(4-fluorobenzyl)-N-(4-sulfamoylphenethyl)acetamide
Summary for 7SUY
Entry DOI | 10.2210/pdb7suy/pdb |
Descriptor | Carbonic anhydrase 2, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N-[(furan-2-yl)methyl]-N-[2-(4-sulfamoylphenyl)ethyl]glycinamide, ... (5 entities in total) |
Functional Keywords | inhibitor, carbonic anhydrase, metal binding protein, lyase-inhibitor complex, lyase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 29369.41 |
Authors | Combs, J.E.,McKenna, R. (deposition date: 2021-11-18, release date: 2022-04-06, Last modification date: 2023-10-18) |
Primary citation | Bonardi, A.,Bua, S.,Combs, J.,Lomelino, C.,Andring, J.,Osman, S.M.,Toti, A.,Di Cesare Mannelli, L.,Gratteri, P.,Ghelardini, C.,McKenna, R.,Nocentini, A.,Supuran, C.T. The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII. J Enzyme Inhib Med Chem, 37:930-939, 2022 Cited by PubMed: 35306936DOI: 10.1080/14756366.2022.2053526 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.405 Å) |
Structure validation
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