7SUP

NMR structure of cTnC-TnI chimera bound to calcium and A1

Summary for 7SUP

• Entry DOI: 10.2210/pdb7sup/pdb
• NMR Information: BMRB: 30962
• Descriptor: Troponin C, slow skeletal and cardiac muscles,Troponin I, cardiac muscle chimera, 4-(3-cyano-3-methylazetidine-1-carbonyl)-N-[(3S)-7-fluoro-6-methyl-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methyl-1H-pyrrole-2-sulfonamide, CALCIUM ION (3 entities in total)
• Functional Keywords: calcium sensitizer, metal binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 14708.69

Authors

Poppe, L.,Hartman, J.J.,Romero, A.,Reagan, J.D. (deposition date: 2021-11-17, release date: 2022-04-06, Last modification date: 2024-05-15)

• Primary citation: Poppe, L.,Hartman, J.J.,Romero, A.,Reagan, J.D.; Structural and Thermodynamic Model for the Activation of Cardiac Troponin.; Biochemistry, 61:741-748, 2022; PubMed: 35349258; DOI: 10.1021/acs.biochem.2c00084

Experimental method

SOLUTION NMR