7SFC
Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3735967A
Summary for 7SFC
Entry DOI | 10.2210/pdb7sfc/pdb |
Descriptor | DNA (cytosine-5)-methyltransferase 1, DNA (12-MER), ZINC ION, ... (8 entities in total) |
Functional Keywords | epigentics, dna methytransferase fold, maintenance methylation, inhibition, dna binding protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 108982.41 |
Authors | Horton, J.R.,Pathuri, S.,Cheng, X. (deposition date: 2021-10-03, release date: 2022-03-30, Last modification date: 2023-10-18) |
Primary citation | Horton, J.R.,Pathuri, S.,Wong, K.,Ren, R.,Rueda, L.,Fosbenner, D.T.,Heerding, D.A.,McCabe, M.T.,Pappalardi, M.B.,Zhang, X.,King, B.W.,Cheng, X. Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30:793-802.e5, 2022 Cited by PubMed: 35395178DOI: 10.1016/j.str.2022.03.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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