7S8V
Leg region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
Summary for 7S8V
Entry DOI | 10.2210/pdb7s8v/pdb |
EMDB information | 24791 24927 |
Descriptor | Insulin-like growth factor 1 receptor, Insulin receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | insulin receptor, type 1 insulin like growth factor receptor, hybrid receptor, insulin like growth factor i, leucine zipper, cryo electron microscopy, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 221288.24 |
Authors | Xu, Y.,Lawrence, M.C. (deposition date: 2021-09-20, release date: 2022-07-06, Last modification date: 2022-08-17) |
Primary citation | Xu, Y.,Margetts, M.B.,Venugopal, H.,Menting, J.G.,Kirk, N.S.,Croll, T.I.,Delaine, C.,Forbes, B.E.,Lawrence, M.C. How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor. Structure, 30:1098-1108.e6, 2022 Cited by PubMed: 35660159DOI: 10.1016/j.str.2022.05.007 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.73 Å) |
Structure validation
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