7S49
Crystal Structure of Inhibitor-bound Galactokinase
Summary for 7S49
Entry DOI | 10.2210/pdb7s49/pdb |
Related | 7RCL |
Descriptor | Galactokinase, alpha-D-galactopyranose, (4R)-2-[(1,3-benzoxazol-2-yl)amino]-4-(4-chloro-1H-pyrazol-5-yl)-4,6,7,8-tetrahydroquinazolin-5(1H)-one, ... (6 entities in total) |
Functional Keywords | galk, galactokinase, galactose, inhibitor, disulfide, sugar binding protein, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 85957.82 |
Authors | Whitby, F.G. (deposition date: 2021-09-08, release date: 2021-09-29, Last modification date: 2023-10-25) |
Primary citation | Liu, L.,Tang, M.,Pragani, R.,Whitby, F.G.,Zhang, Y.Q.,Balakrishnan, B.,Fang, Y.,Karavadhi, S.,Tao, D.,LeClair, C.A.,Hall, M.D.,Marugan, J.J.,Boxer, M.,Shen, M.,Hill, C.P.,Lai, K.,Patnaik, S. Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. J.Med.Chem., 64:13551-13571, 2021 Cited by PubMed: 34491744DOI: 10.1021/acs.jmedchem.1c00945 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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