7S2Y

SAMHD1 HD domain bound to CNDAC

Summary for 7S2Y

• Entry DOI: 10.2210/pdb7s2y/pdb
• Descriptor: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 4-amino-1-{2-cyano-2-deoxy-5-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}pyrimidin-2(1H)-one, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: samhd1, inhibitor, sapacitabine, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 259926.05

Authors

Digianantonio, K.M.,Xiong, Y. (deposition date: 2021-09-04, release date: 2021-10-27, Last modification date: 2023-10-18)

• Primary citation: Rothenburger, T.,Thomas, D.,Schreiber, Y.,Wratil, P.R.,Pflantz, T.,Knecht, K.,Digianantonio, K.,Temple, J.,Schneider, C.,Baldauf, H.M.,McLaughlin, K.M.,Rothweiler, F.,Bilen, B.,Farmand, S.,Bojkova, D.,Costa, R.,Ferreiros, N.,Geisslinger, G.,Oellerich, T.,Xiong, Y.,Keppler, O.T.,Wass, M.N.,Michaelis, M.,Cinatl Jr., J.; Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells.; J Exp Clin Cancer Res, 40:317-317, 2021; PubMed: 34641952; DOI: 10.1186/s13046-021-02093-4

Experimental method

X-RAY DIFFRACTION (2.8 Å)