7RSJ
Structure of the VPS34 kinase domain with compound 14
Summary for 7RSJ
Entry DOI | 10.2210/pdb7rsj/pdb |
Descriptor | Phosphatidylinositol 3-kinase catalytic subunit type 3, SODIUM ION, N-{4-[(7R,8R)-4-oxo-7-(propan-2-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl]pyridin-2-yl}cyclopropanecarboxamide, ... (6 entities in total) |
Functional Keywords | vps34 inhibitor, endosomal trafficking, authophagy, oncoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 70730.55 |
Authors | Hu, D.X.,Patel, S.,Chen, H.,Wang, S.,Staben, S.,Dimitrova, Y.N.,Wallweber, H.A.,Lee, J.Y.,Chan, G.K.Y.,Sneeringer, C.J.,Prangley, M.S.,Moffat, J.G.,Wu, C.,Schutt, L.K.,Salphati, L.,Pang, J.,McNamara, E.,Huang, H.,Chen, Y.,Wang, Y.,Zhao, W.,Lim, J.,Murthy, A.,Siu, M. (deposition date: 2021-08-11, release date: 2021-11-24, Last modification date: 2024-04-03) |
Primary citation | Hu, D.X.,Patel, S.,Chen, H.,Wang, S.,Staben, S.T.,Dimitrova, Y.N.,Wallweber, H.A.,Lee, J.Y.,Chan, G.K.Y.,Sneeringer, C.J.,Prangley, M.S.,Moffat, J.G.,Wu, K.C.,Schutt, L.K.,Salphati, L.,Pang, J.,McNamara, E.,Huang, H.,Chen, Y.,Wang, Y.,Zhao, W.,Lim, J.,Murthy, A.,Siu, M. Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors. J.Med.Chem., 65:11500-11512, 2022 Cited by PubMed: 34779204DOI: 10.1021/acs.jmedchem.1c01180 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.881 Å) |
Structure validation
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