7R62

Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Desmethyl ICI164,384 Derivative

Summary for 7R62

Entry DOI	10.2210/pdb7r62/pdb
Descriptor	Estrogen receptor, 11-[3,17beta-dihydroxyestra-1,3,5(10)-trien-7beta-yl]-N-methyl-N-propylundecanamide (3 entities in total)
Functional Keywords	breast cancer, selective estrogen receptor degrader, alpha helical bundle, antiestrogen, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	28866.99
Authors	Diennet, M.,El Ezzy, M.,Thiombane, K.,Cotnoir-White, D.,Poupart, J.,Gao, Z.,Mendoza Sanchez, R.,Marinier, A.,Gleason, J.,Greene, G.L.,Mader, S.C.,Fanning, S.W. (deposition date: 2021-06-22, release date: 2022-07-06, Last modification date: 2023-10-18)
Primary citation	Fanning, S.W. Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Desmethyl ICI164,384 Derivative To Be Published,
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation