7QWK
GCN2 (EIF2ALPHA KINASE 4, E2AK4) IN COMPLEX WITH COMPOUND 2
Summary for 7QWK
Entry DOI | 10.2210/pdb7qwk/pdb |
Related | 7QQ6 |
Descriptor | eIF-2-alpha kinase GCN2, (2~{S})-~{N}-[(1~{S})-1-[4-[(6-pyridin-4-ylquinazolin-2-yl)amino]phenyl]ethyl]piperidine-2-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | gcn2, eif2 kinase, isr, integrated stress response, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 8 |
Total formula weight | 296900.77 |
Authors | Maia de Oliveira, T. (deposition date: 2022-01-25, release date: 2022-05-04, Last modification date: 2024-02-07) |
Primary citation | Maia de Oliveira, T.,Korboukh, V.,Caswell, S.,Winter Holt, J.J.,Lamb, M.,Hird, A.W.,Overman, R. The structure of human GCN2 reveals a parallel, back-to-back kinase dimer with a plastic DFG activation loop motif. Biochem.J., 477:275-284, 2020 Cited by PubMed: 31868900DOI: 10.1042/BCJ20190196 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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