7Q9S
Crystal structure of PDE6D KRas peptide complex with Compound-1
This is a non-PDB format compatible entry.
Summary for 7Q9S
Entry DOI | 10.2210/pdb7q9s/pdb |
Descriptor | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, KRas, 2-methyl-3-(1~{H}-pyrazol-5-yl)imidazo[1,2-a]pyridine, ... (8 entities in total) |
Functional Keywords | complex, inhibitor, protein binding |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 39357.72 |
Authors | Yelland, T.,Ismail, S. (deposition date: 2021-11-14, release date: 2022-01-19, Last modification date: 2024-01-31) |
Primary citation | Yelland, T.,Garcia, E.,Parry, C.,Kowalczyk, D.,Wojnowska, M.,Gohlke, A.,Zalar, M.,Cameron, K.,Goodwin, G.,Yu, Q.,Zhu, P.C.,ElMaghloob, Y.,Pugliese, A.,Archibald, L.,Jamieson, A.,Chen, Y.X.,McArthur, D.,Bower, J.,Ismail, S. Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling. J.Med.Chem., 65:1898-1914, 2022 Cited by PubMed: 35104933DOI: 10.1021/acs.jmedchem.1c01265 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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