7Q52
Crystal structure of S/T protein kinase PknG from Mycobacterium tuberculosis in complex with inhibitor L2W
This is a non-PDB format compatible entry.
Summary for 7Q52
Entry DOI | 10.2210/pdb7q52/pdb |
Descriptor | Serine/threonine-protein kinase PknG, FE (III) ION, 2-azanyl-3-(4-fluorophenyl)carbonyl-indolizine-1-carboxamide, ... (5 entities in total) |
Functional Keywords | tuberculosis, inhibitor, l2w, transferase |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 1 |
Total formula weight | 36734.39 |
Authors | Defelipe, L.A.,Burastero, O.,Bento, I.,Garcia-Alai, M.M. (deposition date: 2021-11-02, release date: 2022-06-22, Last modification date: 2024-01-31) |
Primary citation | Burastero, O.,Defelipe, L.A.,Gola, G.,Tateosian, N.L.,Lopez, E.D.,Martinena, C.B.,Arcon, J.P.,Traian, M.D.,Wetzler, D.E.,Bento, I.,Barril, X.,Ramirez, J.,Marti, M.A.,Garcia-Alai, M.M.,Turjanski, A.G. Cosolvent Sites-Based Discovery of Mycobacterium Tuberculosis Protein Kinase G Inhibitors. J.Med.Chem., 65:9691-9705, 2022 Cited by PubMed: 35737472DOI: 10.1021/acs.jmedchem.1c02012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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