7PSJ
Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in complex with covalent inhibitor VL166
Summary for 7PSJ
Entry DOI | 10.2210/pdb7psj/pdb |
Descriptor | Beta-glucuronidase, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-(2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid (3 entities in total) |
Functional Keywords | glycoside hydrolase, carbohydrate, glucuronidase, gh79, heparan sulfate |
Biological source | Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161) |
Total number of polymer chains | 1 |
Total formula weight | 51225.92 |
Authors | Armstrong, Z.,Wu, L.,Davies, G.J. (deposition date: 2021-09-23, release date: 2022-08-03, Last modification date: 2024-01-31) |
Primary citation | de Boer, C.,Armstrong, Z.,Lit, V.A.J.,Barash, U.,Ruijgrok, G.,Boyango, I.,Weitzenberg, M.M.,Schroder, S.P.,Sarris, A.J.C.,Meeuwenoord, N.J.,Bule, P.,Kayal, Y.,Ilan, N.,Codee, J.D.C.,Vlodavsky, I.,Overkleeft, H.S.,Davies, G.J.,Wu, L. Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119:e2203167119-e2203167119, 2022 Cited by PubMed: 35881786DOI: 10.1073/pnas.2203167119 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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