7PPF
CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH COMPOUND 8
Summary for 7PPF
Entry DOI | 10.2210/pdb7ppf/pdb |
Descriptor | Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, N-[4-[(4R)-1,4-dimethyl-6-oxidanylidene-4,5-dihydropyridazin-3-yl]phenyl]-5,7-dihydropyrrolo[3,4-b]pyridine-6-carboxamide, ... (5 entities in total) |
Functional Keywords | small molecule inhibitor, nmprtase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 112469.02 |
Authors | Hillig, R.C. (deposition date: 2021-09-13, release date: 2022-06-15, Last modification date: 2024-01-31) |
Primary citation | Bohnke, N.,Berger, M.,Griebenow, N.,Rottmann, A.,Erkelenz, M.,Hammer, S.,Berndt, S.,Gunther, J.,Wengner, A.M.,Stelte-Ludwig, B.,Mahlert, C.,Greven, S.,Dietz, L.,Jorissen, H.,Barak, N.,Bomer, U.,Hillig, R.C.,Eberspaecher, U.,Weiske, J.,Giese, A.,Mumberg, D.,Nising, C.F.,Weinmann, H.,Sommer, A. A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy. Bioconjug.Chem., 33:1210-1221, 2022 Cited by PubMed: 35658441DOI: 10.1021/acs.bioconjchem.2c00178 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.36 Å) |
Structure validation
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