7POT
PI3 kinase delta in complex with N-[5-(3,6-dihydro-2H-pyran-4-yl)-2-methoxypyridin-3-yl]benzenesulfonamide
Summary for 7POT
Entry DOI | 10.2210/pdb7pot/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, N-[5-(3,6-dihydro-2H-pyran-4-yl)-2-methoxy-pyridin-3-yl]benzenesulfonamide (3 entities in total) |
Functional Keywords | pi3 kinase delta, signaling protein |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 108170.07 |
Authors | Rowland, P.,Convery, M. (deposition date: 2021-09-09, release date: 2021-09-29, Last modification date: 2024-06-19) |
Primary citation | Down, K.,Amour, A.,Anderson, N.A.,Barton, N.,Campos, S.,Cannons, E.P.,Clissold, C.,Convery, M.A.,Coward, J.J.,Doyle, K.,Duempelfeld, B.,Edwards, C.D.,Goldsmith, M.D.,Krause, J.,Mallett, D.N.,McGonagle, G.A.,Patel, V.K.,Rowedder, J.,Rowland, P.,Sharpe, A.,Sriskantharajah, S.,Thomas, D.A.,Thomson, D.W.,Uddin, S.,Hamblin, J.N.,Hessel, E.M. Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3K delta with a Novel Binding Mode. J.Med.Chem., 64:13780-13792, 2021 Cited by PubMed: 34510892DOI: 10.1021/acs.jmedchem.1c01102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.391 Å) |
Structure validation
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