7P85
Engineered phosphotriesterase BdPTE 10-2-C3(C59V/C227V) in complex with ethyl-4-methylbenzylphosphonate
Summary for 7P85
Entry DOI | 10.2210/pdb7p85/pdb |
Related | 1PSC |
Descriptor | Parathion hydrolase, ethyl-4-methylbenzylphosphonate, FORMIC ACID, ... (7 entities in total) |
Functional Keywords | bioscavenger, enzyme engineering, organophosphate hydrolase, organophosphorous compound, phosphotriesterase, hydrolase |
Biological source | Brevundimonas diminuta (Pseudomonas diminuta) |
Total number of polymer chains | 1 |
Total formula weight | 38639.95 |
Authors | Eichinger, A.,Skerra, A. (deposition date: 2021-07-21, release date: 2022-08-03, Last modification date: 2024-02-07) |
Primary citation | Job, L.,Kohler, A.,Eichinger, A.,Testanera, M.,Escher, B.,Worek, F.,Skerra, A. Structural and Functional Analysis of a Highly Active Designed Phosphotriesterase for the Detoxification of Organophosphate Nerve Agents Reveals an Unpredicted Conformation of the Active Site Loop. Biochemistry, 62:942-955, 2023 Cited by PubMed: 36752589DOI: 10.1021/acs.biochem.2c00666 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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