7P11
Galectin-8 N-terminal carbohydrate recognition domain in complex with quinoline D-galactal ligand
Summary for 7P11
Entry DOI | 10.2210/pdb7p11/pdb |
Descriptor | Isoform 2 of Galectin-8, Galectin-8, 2-[[(2~{R},3~{R},4~{R})-2-(hydroxymethyl)-3-oxidanyl-3,4-dihydro-2~{H}-pyran-4-yl]oxymethyl]quinoline-7-carboxylic acid, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, galectin, lectin, d-galactal, sugar binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 34747.13 |
Authors | Hassan, M.,Hakansson, M.,Nilsson, J.U.,Kovacic, R. (deposition date: 2021-07-01, release date: 2021-12-15, Last modification date: 2024-01-31) |
Primary citation | Hassan, M.,Baussiere, F.,Guzelj, S.,Sundin, A.P.,Hakansson, M.,Kovacic, R.,Leffler, H.,Tomasic, T.,Anderluh, M.,Jakopin, Z.,Nilsson, U.J. Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain. Acs Med.Chem.Lett., 12:1745-1752, 2021 Cited by PubMed: 34795863DOI: 10.1021/acsmedchemlett.1c00371 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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