7OKD
Crystal structure of human BCL6 BTB domain in complex with compound 25
Summary for 7OKD
Entry DOI | 10.2210/pdb7okd/pdb |
Descriptor | B-cell lymphoma 6 protein, 2-chloranyl-4-[[4-[2-(5-cyclopropylpyrimidin-2-yl)propan-2-ylamino]-1-methyl-2-oxidanylidene-quinolin-6-yl]amino]pyridine-3-carbonitrile, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | cancer, lymphoma, inhibitor, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 17327.39 |
Authors | Gunnell, E.A.,Le Bihan, Y.-V.,van Montfort, R.L.M. (deposition date: 2021-05-17, release date: 2021-12-08, Last modification date: 2024-01-31) |
Primary citation | Lloyd, M.G.,Huckvale, R.,Cheung, K.J.,Rodrigues, M.J.,Collie, G.W.,Pierrat, O.A.,Gatti Iou, M.,Carter, M.,Davis, O.A.,McAndrew, P.C.,Gunnell, E.,Le Bihan, Y.V.,Talbot, R.,Henley, A.T.,Johnson, L.D.,Hayes, A.,Bright, M.D.,Raynaud, F.I.,Meniconi, M.,Burke, R.,van Montfort, R.L.M.,Rossanese, O.W.,Bellenie, B.R.,Hoelder, S. Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket. J.Med.Chem., 64:17079-17097, 2021 Cited by PubMed: 34846884DOI: 10.1021/acs.jmedchem.1c00946 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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