7NH4

Co-Crystal Structure of Akt1 in Complex with Covalent-Allosteric Akt Inhibitor 3

Summary for 7NH4

Entry DOI	10.2210/pdb7nh4/pdb
Descriptor	RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-[5-(hydroxymethyl)-3-phenyl-pyridin-2-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide, ACETATE ION, ... (4 entities in total)
Functional Keywords	akt1, akt2, akt3, covalent-allosteric, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	52425.80
Authors	Landel, I.,Mueller, M.P.,Rauh, D. (deposition date: 2021-02-10, release date: 2021-09-08, Last modification date: 2024-01-31)
Primary citation	Quambusch, L.,Depta, L.,Landel, I.,Lubeck, M.,Kirschner, T.,Nabert, J.,Uhlenbrock, N.,Weisner, J.,Kostka, M.,Levy, L.M.,Schultz-Fademrecht, C.,Glanemann, F.,Althoff, K.,Muller, M.P.,Siveke, J.T.,Rauh, D. Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Nat Commun, 12:5297-5297, 2021 Cited by PubMed: 34489430 DOI: 10.1038/s41467-021-25512-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation