7NG1
Crystal structure of alpha Carbonic anhydrase from Schistoso ma mansoni bound to 1-(4-iodophenyl)-3-[2-(4-sulfamoylphenyl)ethyl]selenourea
Summary for 7NG1
Entry DOI | 10.2210/pdb7ng1/pdb |
Descriptor | Carbonic anhydrase, ~{N}'-(4-iodophenyl)-~{N}-[2-(4-sulfamoylphenyl)ethyl]carbamimidoselenoic acid, ZINC ION, ... (6 entities in total) |
Functional Keywords | lyase |
Biological source | Schistosoma mansoni (Blood fluke) |
Total number of polymer chains | 2 |
Total formula weight | 77987.25 |
Authors | Ferraroni, M.,Angeli, A.,Supuran, C.T. (deposition date: 2021-02-08, release date: 2022-03-02, Last modification date: 2024-01-31) |
Primary citation | Angeli, A.,Ferraroni, M.,Da'dara, A.A.,Selleri, S.,Pinteala, M.,Carta, F.,Skelly, P.J.,Supuran, C.T. Structural Insights into Schistosoma mansoni Carbonic Anhydrase (SmCA) Inhibition by Selenoureido-Substituted Benzenesulfonamides. J.Med.Chem., 64:10418-10428, 2021 Cited by PubMed: 34232641DOI: 10.1021/acs.jmedchem.1c00840 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.67 Å) |
Structure validation
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