7MQU
The haddock model of GDP KRas in complex with promethazine using NMR chemical shift perturbations
Summary for 7MQU
Entry DOI | 10.2210/pdb7mqu/pdb |
NMR Information | BMRB: 30906 |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | kras, allosteric inhibitor, drug discovery, haddock, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 20023.69 |
Authors | Wang, X.,Gorfe, A.A.,Putkey, J.P. (deposition date: 2021-05-06, release date: 2022-05-11, Last modification date: 2024-05-15) |
Primary citation | Wang, X.,Gorfe, A.A.,Putkey, J.A. Antipsychotic phenothiazine drugs bind to KRAS in vitro. J.Biomol.Nmr, 75:233-244, 2021 Cited by PubMed: 34176062DOI: 10.1007/s10858-021-00371-z PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report