7MFH
Crystal structure of BIO-32546 bound mouse Autotaxin
Summary for 7MFH
Entry DOI | 10.2210/pdb7mfh/pdb |
Descriptor | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | hydrolase inhibitor, autotaxin, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 99445.25 |
Authors | Chodaparambil, J.V. (deposition date: 2021-04-09, release date: 2022-04-13, Last modification date: 2023-10-18) |
Primary citation | Ma, B.,Zhang, L.,Sun, L.,Xin, Z.,Kumaravel, G.,Marcotte, D.,Chodaparambil, J.V.,Wang, Q.,Wehr, A.,Jing, J.,Hong, V.S.,Wang, T.,Huang, C.,Shao, Z.,Mi, S. Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546. Acs Med.Chem.Lett., 12:1124-1129, 2021 Cited by PubMed: 34267882DOI: 10.1021/acsmedchemlett.1c00211 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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