7MFC

Crystal structure of CSF1R in complex with vimseltinib

Summary for 7MFC

• Entry DOI: 10.2210/pdb7mfc/pdb
• Descriptor: Macrophage colony-stimulating factor 1 receptor, Vimseltinib (3 entities in total)
• Functional Keywords: cancer, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 39071.67

Authors

Abendroth, J.,Davies, D.R.,Atkins, K. (deposition date: 2021-04-08, release date: 2021-11-24, Last modification date: 2023-10-18)

• Primary citation: Smith, B.D.,Kaufman, M.D.,Wise, S.C.,Ahn, Y.M.,Caldwell, T.M.,Leary, C.B.,Lu, W.P.,Tan, G.,Vogeti, L.,Vogeti, S.,Wilky, B.A.,Davis, L.E.,Sharma, M.,Ruiz-Soto, R.,Flynn, D.L.; Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages.; Mol.Cancer Ther., 20:2098-2109, 2021; PubMed: 34433663; DOI: 10.1158/1535-7163.MCT-21-0361

Experimental method

X-RAY DIFFRACTION (2.8 Å)