7MB2
SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM144
Summary for 7MB2
Entry DOI | 10.2210/pdb7mb2/pdb |
Descriptor | 3C-like proteinase, 4-fluoro-N-{3-[(prop-2-yn-1-yl)oxy]propanoyl}-D-phenylalanyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide (3 entities in total) |
Functional Keywords | sars-cov-2, covid-19, covid19 protease, protease inhibitor, covalent, covalent inhibitor, complex, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) |
Total number of polymer chains | 2 |
Total formula weight | 68952.57 |
Authors | Lockbaum, G.J.,Schiffer, C.A. (deposition date: 2021-03-31, release date: 2022-10-12, Last modification date: 2023-10-18) |
Primary citation | Lockbaum, G.J.,Schiffer, C.A. SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM144 To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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