7M41
Structure of TIM-3 in complex with N-(4-(8-chloro-2-methyl-5-oxo-5,6-dihydro-[1,2,4]traizolo[1,5-c]quinazolin-9-yl)-3-methylphenyl)-1H-imidazole-2-sulfonamide (compound 38)
Summary for 7M41
Entry DOI | 10.2210/pdb7m41/pdb |
Related | 7M3Y 7M3Z |
Descriptor | Hepatitis A virus cellular receptor 2, N-{4-[(4S,10aP)-8-chloro-2-methyl-5-oxo-5,6-dihydro[1,2,4]triazolo[1,5-c]quinazolin-9-yl]-3-methylphenyl}-1H-imidazole-2-sulfonamide, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | igv, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 25615.97 |
Authors | Rietz, T.A. (deposition date: 2021-03-19, release date: 2021-10-13, Last modification date: 2023-10-18) |
Primary citation | Rietz, T.A.,Teuscher, K.B.,Mills, J.J.,Gogliotti, R.D.,Lepovitz, L.T.,Scaggs, W.R.,Yoshida, K.,Luong, K.,Lee, T.,Fesik, S.W. Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3). J.Med.Chem., 64:14757-14772, 2021 Cited by PubMed: 34597046DOI: 10.1021/acs.jmedchem.1c01336 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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