7LXL
Crystal structure of human CYP3A4 bound to the testosterone dimer
Summary for 7LXL
Entry DOI | 10.2210/pdb7lxl/pdb |
Descriptor | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, 17alpha-hydroxy-7alpha-[(2Z)-4-(17beta-hydroxy-3-oxo-8alpha-androst-4-en-7beta-yl)but-2-en-1-yl]-8alpha,10alpha,13alpha,14beta-androst-4-en-3-one (3 entities in total) |
Functional Keywords | cyp3a4, ligand, testosterone dimer, complex, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 56872.02 |
Authors | Sevrioukova, I.F. (deposition date: 2021-03-04, release date: 2021-04-28, Last modification date: 2023-10-18) |
Primary citation | Paquin, A.,Oufqir, Y.,Sevrioukova, I.F.,Reyes-Moreno, C.,Berube, G. Innovative C 2 -symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4. Eur.J.Med.Chem., 220:113496-113496, 2021 Cited by PubMed: 33933755DOI: 10.1016/j.ejmech.2021.113496 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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