7LTY
Bruton's tyrosine kinase in complex with compound 23
Summary for 7LTY
Entry DOI | 10.2210/pdb7lty/pdb |
Related | 6W07 |
Descriptor | Isoform BTK-C of Tyrosine-protein kinase BTK, ~{N}-[(5~{R})-2-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-6,7,8,9-tetrahydro-5~{H}-benzo[7]annulen-5-yl]-3-propan-2-yloxy-azetidine-1-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | transferase, transferase inhibitor, kinase, kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 31761.57 |
Authors | Metrick, C.M.,Marcotte, D.J. (deposition date: 2021-02-20, release date: 2022-01-12, Last modification date: 2023-10-18) |
Primary citation | Hopkins, B.T.,Bame, E.,Bajrami, B.,Black, C.,Bohnert, T.,Boiselle, C.,Burdette, D.,Burns, J.C.,Delva, L.,Donaldson, D.,Grater, R.,Gu, C.,Hoemberger, M.,Johnson, J.,Kapadnis, S.,King, K.,Lulla, M.,Ma, B.,Marx, I.,Magee, T.,Meissner, R.,Metrick, C.M.,Mingueneau, M.,Murugan, P.,Otipoby, K.L.,Polack, E.,Poreci, U.,Prince, R.,Roach, A.M.,Rowbottom, C.,Santoro, J.C.,Schroeder, P.,Tang, H.,Tien, E.,Zhang, F.,Lyssikatos, J. Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis. J.Med.Chem., 65:1206-1224, 2022 Cited by PubMed: 34734694DOI: 10.1021/acs.jmedchem.1c00926 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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