7LTG
STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH APICIDIN
Summary for 7LTG
Entry DOI | 10.2210/pdb7ltg/pdb |
Descriptor | Histone deacetylase 2, ZINC ION, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | histone deacetylase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 132609.25 |
Authors | Klein, D.J.,Beshore, D.C. (deposition date: 2021-02-19, release date: 2021-05-05, Last modification date: 2024-03-06) |
Primary citation | Beshore, D.C.,Adam, G.C.,Barnard, R.J.O.,Burlein, C.,Gallicchio, S.N.,Holloway, M.K.,Krosky, D.,Lemaire, W.,Myers, R.W.,Patel, S.,Plotkin, M.A.,Powell, D.A.,Rada, V.,Cox, C.D.,Coleman, P.J.,Klein, D.J.,Wolkenberg, S.E. Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction. Acs Med.Chem.Lett., 12:540-547, 2021 Cited by PubMed: 33854701DOI: 10.1021/acsmedchemlett.1c00074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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