7KXF
CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C (NHIS-RORGT(244-487)-L6-SRC1(678-692)) IN COMPLEX WITH {3,5-DICHLORO-4-[4-METHOXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}METHANOL
Summary for 7KXF
Entry DOI | 10.2210/pdb7kxf/pdb |
Descriptor | Nuclear receptor ROR-gamma, Nuclear receptor coactivator 1 chimera, N-(3,5-dichloro-4-{[6-methoxy-5-(propan-2-yl)pyridin-3-yl]oxy}phenyl)-2-[1-(methylsulfonyl)piperidin-4-yl]acetamide (3 entities in total) |
Functional Keywords | rorgt, nuclear hormone receptor, ligand-binding domain, inverse agonist, transferase-agonist complex, transferase/agonist |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 33417.39 |
Authors | Sack, J. (deposition date: 2020-12-03, release date: 2021-01-20, Last modification date: 2023-10-18) |
Primary citation | Ruan, Z.,Park, P.K.,Wei, D.,Purandare, A.,Wan, H.,O'Malley, D.,Stachura, S.,Perez, H.,Cavallaro, C.L.,Weigelt, C.A.,Sack, J.S.,Ruzanov, M.,Khan, J.,Gururajan, M.,Wong, J.J.,Huang, Y.,Yarde, M.,Li, Z.,Chen, C.,Sun, H.,Borowski, V.,Xie, J.H.,Anthony, M.,Agler, M.,Fink, B.E.,Harikrishnan, L.S. Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-gamma t (ROR gamma t) agonists. Bioorg.Med.Chem.Lett., 35:127778-127778, 2021 Cited by PubMed: 33422603DOI: 10.1016/j.bmcl.2021.127778 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.141 Å) |
Structure validation
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