7KSK
Thiophenyl-Pyrazolourea Derivatives as Potent, Brian Penetrant, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors
Summary for 7KSK
Entry DOI | 10.2210/pdb7ksk/pdb |
Descriptor | Mitogen-activated protein kinase 10, 4-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(oxetan-3-yl)thiophene-2-carboxamide (3 entities in total) |
Functional Keywords | jnk3, kinase inhibitor, alzheimer disease, pyrazolourea, neurodegeneration, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 53067.20 |
Authors | Park, H. (deposition date: 2020-11-23, release date: 2021-03-03, Last modification date: 2023-10-18) |
Primary citation | Feng, Y.,Park, H.,Bauer, L.,Ryu, J.C.,Yoon, S.O. Thiophene-Pyrazolourea Derivatives as Potent, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors. Acs Med.Chem.Lett., 12:24-29, 2021 Cited by PubMed: 33488960DOI: 10.1021/acsmedchemlett.0c00533 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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