7KN7

Crystal structure of SARS-CoV-2 receptor binding domain complexed with nanobody VHH W and antibody Fab CC12.3

Summary for 7KN7

• Entry DOI: 10.2210/pdb7kn7/pdb
• Descriptor: Spike protein S1, VHH W, CC12.3 Fab heavy chain, ... (5 entities in total)
• Functional Keywords: sars-cov-2, nanobody, spike, coronavirus, covid-19, immune system, nanobody-antigen complex, single-domain antibody, antibody, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 4
• Total formula weight: 88311.22

Authors

Liu, H.,Yuan, M.,Zhu, X.,Wu, N.C.,Wilson, I.A. (deposition date: 2020-11-04, release date: 2021-01-20, Last modification date: 2023-10-18)

• Primary citation: Koenig, P.A.,Das, H.,Liu, H.,Kummerer, B.M.,Gohr, F.N.,Jenster, L.M.,Schiffelers, L.D.J.,Tesfamariam, Y.M.,Uchima, M.,Wuerth, J.D.,Gatterdam, K.,Ruetalo, N.,Christensen, M.H.,Fandrey, C.I.,Normann, S.,Todtmann, J.M.P.,Pritzl, S.,Hanke, L.,Boos, J.,Yuan, M.,Zhu, X.,Schmid-Burgk, J.L.,Kato, H.,Schindler, M.,Wilson, I.A.,Geyer, M.,Ludwig, K.U.,Hallberg, B.M.,Wu, N.C.,Schmidt, F.I.; Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.; Science, 371:-, 2021; PubMed: 33436526; DOI: 10.1126/science.abe6230

Experimental method

X-RAY DIFFRACTION (2.73 Å)