7KMS

Cryo-EM structure of triple ACE2-bound SARS-CoV-2 trimer spike at pH 7.4

Summary for 7KMS

• Entry DOI: 10.2210/pdb7kms/pdb
• Related: 7KMB
• EMDB information: 22927
• Descriptor: Angiotensin-converting enzyme 2, Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: covid, covid19, sars-cov2, ace2, prefusion, hydrolase-viral protein complex, hydrolase/viral protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 650220.77

Authors

Gorman, J.,Kwong, P.D.,Shapiro, L. (deposition date: 2020-11-03, release date: 2020-12-09, Last modification date: 2021-12-15)

• Primary citation: Zhou, T.,Tsybovsky, Y.,Gorman, J.,Rapp, M.,Cerutti, G.,Chuang, G.Y.,Katsamba, P.S.,Sampson, J.M.,Schon, A.,Bimela, J.,Boyington, J.C.,Nazzari, A.,Olia, A.S.,Shi, W.,Sastry, M.,Stephens, T.,Stuckey, J.,Teng, I.T.,Wang, P.,Wang, S.,Zhang, B.,Friesner, R.A.,Ho, D.D.,Mascola, J.R.,Shapiro, L.,Kwong, P.D.; Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.; Cell Host Microbe, 28:867-879.e5, 2020; PubMed: 33271067; DOI: 10.1016/j.chom.2020.11.004

Experimental method

ELECTRON MICROSCOPY (3.64 Å)