7KKE

Phosphoinositide 3-Kinase gamma bound to a thiazole inhibitor

Summary for 7KKE

Entry DOI	10.2210/pdb7kke/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, N-[2-(3,3-dimethylbutoxy)ethyl]-N'-{4-methyl-5-[(pyridin-4-yl)ethynyl]-1,3-thiazol-2-yl}urea (3 entities in total)
Functional Keywords	kinase, inhibitor, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	111655.27
Authors	Jacobs, M.D.,Griffith, J.P. (deposition date: 2020-10-27, release date: 2021-03-24, Last modification date: 2023-10-18)
Primary citation	Bandarage, U.K.,Aronov, A.M.,Cao, J.,Come, J.H.,Cottrell, K.M.,Davies, R.J.,Giroux, S.,Jacobs, M.,Mahajan, S.,Messersmith, D.,Moody, C.S.,Swett, R.,Xu, J. Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3K gamma Inhibitors. Acs Med.Chem.Lett., 12:129-135, 2021 Cited by PubMed: 33488974 DOI: 10.1021/acsmedchemlett.0c00573 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.81 Å)

Structure validation