7K7Z
Structure of a hit for G Protein Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure
Summary for 7K7Z
Entry DOI | 10.2210/pdb7k7z/pdb |
Related | 7k7l |
Descriptor | Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (4 entities in total) |
Functional Keywords | serine/threonine protein kinase, signaling protein, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 118653.23 |
Authors | Spurlino, J.C.,Milligan, C. (deposition date: 2020-09-24, release date: 2020-10-28, Last modification date: 2024-04-03) |
Primary citation | Xu, G.,Gaul, M.D.,Liu, Z.,DesJarlais, R.L.,Qi, J.,Wang, W.,Krosky, D.,Petrounia, I.,Milligan, C.M.,Hermans, A.,Lu, H.R.,Huang, D.Z.,Xu, J.Z.,Spurlino, J.C. Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor. Bioorg.Med.Chem.Lett., 30:127602-127602, 2020 Cited by PubMed: 33038544DOI: 10.1016/j.bmcl.2020.127602 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.60608692764 Å) |
Structure validation
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