7K4I
Human Arginase 1 in complex with compound 06.
Summary for 7K4I
Entry DOI | 10.2210/pdb7k4i/pdb |
Descriptor | Arginase-1, MANGANESE (II) ION, 3-[(1~{S},2~{S},5~{R})-2-carboxy-6-thia-3-azabicyclo[3.2.0]heptan-1-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide, ... (4 entities in total) |
Functional Keywords | arginase, hydrolase, arginine, urea cycle, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 210911.20 |
Authors | Palte, R.L. (deposition date: 2020-09-15, release date: 2021-10-06, Last modification date: 2023-10-18) |
Primary citation | Li, D.,Zhang, H.,Lyons, T.W.,Lu, M.,Achab, A.,Pu, Q.,Childers, M.,Mitcheltree, M.J.,Wang, J.,Martinot, T.A.,McMinn, S.E.,Sloman, D.L.,Palani, A.,Beard, A.,Nogle, L.,Gathiaka, S.,Sauri, J.,Kim, H.Y.,Adpressa, D.,Spacciapoli, P.,Miller, J.R.,Palte, R.L.,Lesburg, C.A.,Cumming, J.,Fischer, C. Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors. Acs Med.Chem.Lett., 12:1678-1688, 2021 Cited by PubMed: 34795856DOI: 10.1021/acsmedchemlett.1c00258 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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