7JYS
hALK in complex with 3-(3-chlorophenyl)-5-methyl-1H-pyrazole
Summary for 7JYS
Entry DOI | 10.2210/pdb7jys/pdb |
Related | 7JYR |
Descriptor | ALK tyrosine kinase receptor, 3-(3-chlorophenyl)-5-methyl-1H-pyrazole, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | alk tyrosine kinase receptor, inhibitor, complex, kinase, sbdd, transferase-inhibitor complex, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36300.08 |
Authors | McGrath, A.P.,Zou, H.,Lane, W.,Saikatendu, K. (deposition date: 2020-08-31, release date: 2021-01-20, Last modification date: 2023-10-18) |
Primary citation | Fujimori, I.,Wakabayashi, T.,Murakami, M.,Okabe, A.,Ishii, T.,McGrath, A.,Zou, H.,Saikatendu, K.S.,Imoto, H. Discovery of Novel and Highly Selective Cyclopropane ALK Inhibitors through a Fragment-Assisted, Structure-Based Drug Design. Acs Omega, 5:31984-32001, 2020 Cited by PubMed: 33344853DOI: 10.1021/acsomega.0c04900 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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