7JYQ

JAK2 JH2 in complex with JAK020

Summary for 7JYQ

• Entry DOI: 10.2210/pdb7jyq/pdb
• Descriptor: Tyrosine-protein kinase JAK2, GLYCEROL, N~2~-(4-fluorophenyl)-6-{[(5-{[(oxolan-2-yl)methyl]amino}-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-1,3,5-triazine-2,4-diamine, ... (4 entities in total)
• Functional Keywords: pseudokinase domain, inhibitor, complex, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 33647.57

Authors

Puleo, D.E.,Krimmer, S.G.,Newton, A.S.,Schlessinger, J.,Jorgensen, W.L. (deposition date: 2020-08-31, release date: 2021-07-14, Last modification date: 2023-10-18)

• Primary citation: Newton, A.S.,Liosi, M.E.,Henry, S.P.,Deiana, L.,Faver, J.C.,Krimmer, S.G.,Puleo, D.E.,Schlessinger, J.,Jorgensen, W.L.; Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant; Tetrahedron Lett., 77:153248-, 2021; DOI: 10.1016/j.tetlet.2021.153248

Experimental method

X-RAY DIFFRACTION (1.85941610301 Å)