7I97

Crystal Structure of 8 bound to the PH domain of Btk

Summary for 7I97

Entry DOI	10.2210/pdb7i97/pdb
Group deposition	Btk ph domain (G_1002333)
Descriptor	Tyrosine-protein kinase BTK, (6R)-6-(2-fluorophenyl)-4,5,6,7-tetrahydro-1-benzofuran-3-carboxylic acid, ZINC ION, ... (5 entities in total)
Functional Keywords	fragment based drug discovery, ph domain, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	81243.39
Authors	Brear, P.,West, R.M.,Nicolescu, R.C.B.,Blaszczyk, B.K.,Anwar, A.,Deingruber, T.,Sanders, M.G.,Perez-Areales, F.J.,Stephens, L.R.,Hawkins, P.T.,Spring, D.R.,Hyvonen, M. (deposition date: 2025-03-24, release date: 2026-05-20)
Primary citation	Brear, P.,West, R.M.,Nicolescu, R.C.B.,Blaszczyk, B.K.,Anwar, A.,Deingruber, T.,Sanders, M.G.,Perez-Areales, F.J.,Stephens, L.R.,Hawkins, P.T.,Spring, D.R.,Hyvonen, M. Inhibition of a Pleckstrin Homology Domain by Lysine-reactive Covalent Inhibitor To be published,
Experimental method	X-RAY DIFFRACTION (1.692 Å)

Structure validation