7FVT
Crystal Structure of S. aureus gyrase in complex with 6-[5-[2-[(4-chloro-2,3-dihydro-1H-inden-2-yl)methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Summary for 7FVT
Entry DOI | 10.2210/pdb7fvt/pdb |
Group deposition | A set of S. aureus gyrase BA fusion crystal structures (G_1002266) |
Descriptor | DNA gyrase subunit B,DNA gyrase subunit A Chimera, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), MANGANESE (II) ION, ... (6 entities in total) |
Functional Keywords | dna gyrase, topoisomerase;, isomerase |
Biological source | Staphylococcus aureus subsp. aureus N315 More |
Total number of polymer chains | 4 |
Total formula weight | 169203.98 |
Authors | Xu, B.,Benz, J.,Cumming, J.G.,Rudolph, M.G. (deposition date: 2023-04-18, release date: 2023-06-28, Last modification date: 2023-08-16) |
Primary citation | Cumming, J.G.,Kreis, L.,Kuhne, H.,Wermuth, R.,Vercruysse, M.,Kramer, C.,Rudolph, M.G.,Xu, Z. Discovery of a Series of Indane-Containing NBTIs with Activity against Multidrug-Resistant Gram-Negative Pathogens. Acs Med.Chem.Lett., 14:993-998, 2023 Cited by PubMed: 37465290DOI: 10.1021/acsmedchemlett.3c00187 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.081 Å) |
Structure validation
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