7FS7
Structure of liver pyruvate kinase in complex with allosteric modulator 20
Summary for 7FS7
Entry DOI | 10.2210/pdb7fs7/pdb |
Group deposition | Sulfonamide-containing catechols as modulators of liver pyruvate kinase (G_1002240) |
Descriptor | Pyruvate kinase PKLR, 1,6-di-O-phosphono-beta-D-fructofuranose, OXALATE ION, ... (7 entities in total) |
Functional Keywords | pyruvate kinase, active site, inhibition, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 391894.03 |
Authors | Lulla, A.,Nilsson, O.,Brear, P.,Nain-Perez, A.,Grotli, M.,Hyvonen, M. (deposition date: 2022-12-18, release date: 2023-04-12, Last modification date: 2024-05-22) |
Primary citation | Nain-Perez, A.,Nilsson, O.,Lulla, A.,Haversen, L.,Brear, P.,Liljenberg, S.,Hyvonen, M.,Boren, J.,Grotli, M. Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators. Eur.J.Med.Chem., 250:115177-115177, 2023 Cited by PubMed: 36753880DOI: 10.1016/j.ejmech.2023.115177 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.774 Å) |
Structure validation
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