7FBK

Crystal structure of SARS-CoV-2 receptor binding domain N501Y mutant in complex with neutralizing nanobody 20G6

Summary for 7FBK

• Entry DOI: 10.2210/pdb7fbk/pdb
• Descriptor: Spike protein S1, New antigen receptor variable domain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: sars-cov-2, spike glycoprotein, rbd, vnar, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 4
• Total formula weight: 81267.94

Authors

Zhu, J.,Xu, T.,Feng, B.,Liu, J. (deposition date: 2021-07-11, release date: 2022-07-13, Last modification date: 2023-11-29)

• Primary citation: Feng, B.,Chen, Z.,Sun, J.,Xu, T.,Wang, Q.,Yi, H.,Niu, X.,Zhu, J.,Fan, M.,Hou, R.,Shao, Y.,Huang, S.,Li, C.,Hu, P.,Zheng, P.,He, P.,Luo, J.,Yan, Q.,Xiong, X.,Liu, J.,Zhao, J.,Chen, L.; A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape.; Small Methods, 6:e2200387-e2200387, 2022; PubMed: 35583124; DOI: 10.1002/smtd.202200387

Experimental method

X-RAY DIFFRACTION (1.9 Å)