7F29

Cryo-EM structure of the fibril formed by disaccharide-modified amyloid-beta(1-42)

Summary for 7F29

Entry DOI	10.2210/pdb7f29/pdb
EMDB information	31428
Descriptor	Amyloid-beta A4 protein, beta-D-galactopyranose-(1-3)-2-amino-2-deoxy-alpha-D-galactopyranose, ACETIC ACID (3 entities in total)
Functional Keywords	amyloid fibril, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	6
Total formula weight	25810.82
Authors	Xia, W.C.,Sun, Y.P.,Liu, C. (deposition date: 2021-06-10, release date: 2022-07-13, Last modification date: 2024-06-12)
Primary citation	Liu, D.,Wei, Q.,Xia, W.,He, C.,Zhang, Q.,Huang, L.,Wang, X.,Sun, Y.,Ma, Y.,Zhang, X.,Wang, Y.,Shi, X.,Liu, C.,Dong, S. O-Glycosylation Induces Amyloid-beta To Form New Fibril Polymorphs Vulnerable for Degradation J.Am.Chem.Soc., 143:20216-20223, 2021 Cited by DOI: 10.1021/jacs.1c08607 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.1 Å)

Structure validation