7EMJ

Crystal structure of T2R-TTL-Barbigerone complex

Summary for 7EMJ

Entry DOI	10.2210/pdb7emj/pdb
Descriptor	Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywords	tubulin, cancer, cell cycle-inhibitor complex, cell cycle/inhibitor
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	6
Total formula weight	270197.82
Authors	Yang, J.H.,Yan, W. (deposition date: 2021-04-14, release date: 2022-04-20, Last modification date: 2024-07-10)
Primary citation	Yan, W.,Li, Y.,Liu, Y.,Wen, Y.,Pei, H.,Yang, J.,Chen, L. Crystal structure of tubulin-barbigerone complex enables rational design of potent anticancer agents with isoflavone skeleton. Phytomedicine, 109:154550-154550, 2023 Cited by PubMed: 36610121 DOI: 10.1016/j.phymed.2022.154550 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation