7ELV

Structure of legume lectin domain from Methanocaldococcus jannaschii in apo form

Summary for 7ELV

• Entry DOI: 10.2210/pdb7elv/pdb
• Descriptor: legume lectin, (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, ... (6 entities in total)
• Functional Keywords: lectin, sugar binding protein
• Biological source: Methanocaldococcus jannaschii DSM 2661 (Methanococcus jannaschii)
• Total number of polymer chains: 1
• Total formula weight: 23295.47

Authors

Suguna, K.,Khan, F. (deposition date: 2021-04-12, release date: 2022-04-20, Last modification date: 2023-11-29)

Primary citation

Khan, F.,Kaza, S.
Crystal structure of an L-type lectin domain from archaea.
Proteins, 91:456-465, 2023

PubMed Abstract: The crystal structures of an L-type lectin domain from Methanocaldococcus jannaschii in apo and mannose-bound forms have been determined. A thorough investigation of L-type lectin domains from several organisms provides insight into the differences in these domains from different kingdoms of life. While the overall fold of the L-type lectin domain is conserved, differences in the lengths of the carbohydrate-binding loops and significant variations in the Mn -binding site compared to the Ca -binding site are observed. Furthermore, the sequence and phylogenetic analyses suggest that the archaeal L-type lectin domain is evolutionarily closer to the plant legume lectins than to its bacterial or animal counterparts. This is the first report of the biochemical, structural, sequence, and phylogenetic analyses of an L-type lectin domain from archaea and serves to enhance our understanding of the species-specific differences and evolution of L-type lectin domains.

PubMed: 36301308
DOI: 10.1002/prot.26440

Experimental method

X-RAY DIFFRACTION (1.5 Å)