7EI4

Crystal structure of MasL in complex with a novel covalent inhibitor, collimonin C

Summary for 7EI4

Entry DOI	10.2210/pdb7ei4/pdb
Descriptor	Acetyl-CoA C-acyltransferase, (6S,7R,9E)-6,7-bis(oxidanyl)hexadeca-9,15-dien-11,13-diynoic acid (3 entities in total)
Functional Keywords	acetyl-coa acetyltransferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	[Empedobacter] haloabium
Total number of polymer chains	4
Total formula weight	171534.64
Authors	Lin, C.C.,Huang, K.F.,Yang, Y.L. (deposition date: 2021-03-30, release date: 2022-04-06, Last modification date: 2023-11-29)
Primary citation	Lin, C.C.,Hoo, S.Y.,Ma, L.T.,Lin, C.,Huang, K.F.,Ho, Y.N.,Sun, C.H.,Lee, H.J.,Chen, P.Y.,Shu, L.J.,Wang, B.W.,Hsu, W.C.,Ko, T.P.,Yang, Y.L. Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors. Commun Biol, 5:454-454, 2022 Cited by PubMed: 35551233 DOI: 10.1038/s42003-022-03409-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.66 Å)

Structure validation