7EAZ

Cryo-EM structure of SARS-CoV-2 Spike D614G variant, one RBD-up conformation 1

Summary for 7EAZ

Entry DOI	10.2210/pdb7eaz/pdb
EMDB information	31047
Descriptor	Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	sars-cov-2, spike protein, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
Total number of polymer chains	3
Total formula weight	443979.33
Authors	Yang, T.J.,Yu, P.Y.,Chang, Y.C.,Hsu, S.T.D. (deposition date: 2021-03-08, release date: 2021-06-23, Last modification date: 2022-01-05)
Primary citation	Yang, T.J.,Yu, P.Y.,Chang, Y.C.,Hsu, S.D. D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation. J.Biol.Chem., 297:101238-101238, 2021 Cited by PubMed: 34563540 DOI: 10.1016/j.jbc.2021.101238 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation