7DQ6
Crystal structure of HitB in complex with (S)-beta-3-Br-phenylalanine sulfamoyladenosine
Summary for 7DQ6
Entry DOI | 10.2210/pdb7dq6/pdb |
Descriptor | Putative ATP-dependent b-aminoacyl-ACP synthetase, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl N-[(3S)-3-azanyl-3-(3-bromophenyl)propanoyl]sulfamate, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | hitachimycin, polyketide biosynthesis, atp binding, adenylation, ligase |
Biological source | Embleya scabrispora |
Total number of polymer chains | 2 |
Total formula weight | 120574.33 |
Authors | Kudo, F.,Takahashi, S.,Miyanaga, A.,Nakazawa, Y.,Eguchi, T. (deposition date: 2020-12-22, release date: 2021-03-03, Last modification date: 2023-11-29) |
Primary citation | Kudo, F.,Takahashi, S.,Miyanaga, A.,Nakazawa, Y.,Nishino, K.,Hayakawa, Y.,Kawamura, K.,Ishikawa, F.,Tanabe, G.,Iwai, N.,Nagumo, Y.,Usui, T.,Eguchi, T. Mutational Biosynthesis of Hitachimycin Analogs Controlled by the beta-Amino Acid-Selective Adenylation Enzyme HitB. Acs Chem.Biol., 16:539-547, 2021 Cited by PubMed: 33625847DOI: 10.1021/acschembio.1c00003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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