7DF5

Human Galectin-3 CRD in complex with novel tetrahydropyran-based thiodisaccharide mimic inhibitor

Summary for 7DF5

• Entry DOI: 10.2210/pdb7df5/pdb
• Related: 7DF6
• Descriptor: Galectin-3, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, galectin-3 crd, carbohydrate
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 19367.88

Authors

Ghosh, K.,Kumar, A. (deposition date: 2020-11-06, release date: 2021-06-23, Last modification date: 2023-11-29)

• Primary citation: Xu, L.,Hartz, R.A.,Beno, B.R.,Ghosh, K.,Shukla, J.K.,Kumar, A.,Patel, D.,Kalidindi, N.,Lemos, N.,Gautam, S.S.,Kumar, A.,Ellsworth, B.A.,Shah, D.,Sale, H.,Cheng, D.,Regueiro-Ren, A.; Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors.; J.Med.Chem., 64:6634-6655, 2021; PubMed: 33988358; DOI: 10.1021/acs.jmedchem.0c02001

Experimental method

X-RAY DIFFRACTION (1.08 Å)