7DCF
Crystal structure of EHMT2 SET domain in complex with compound 10
Summary for 7DCF
Entry DOI | 10.2210/pdb7dcf/pdb |
Descriptor | Histone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYLMETHIONINE, ... (5 entities in total) |
Functional Keywords | protein-small molecule inhibitor complex, transferase-transferase inhibitor complex, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 67152.84 |
Authors | Suzuki, M.,Katayama, K. (deposition date: 2020-10-26, release date: 2021-02-10, Last modification date: 2024-03-27) |
Primary citation | Katayama, K.,Ishii, K.,Terashima, H.,Tsuda, E.,Suzuki, M.,Yotsumoto, K.,Hiramoto, K.,Yasumatsu, I.,Torihata, M.,Ishiyama, T.,Muto, T.,Katagiri, T. Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating beta-Thalassemia and Sickle Cell Disease. Acs Med.Chem.Lett., 12:121-128, 2021 Cited by PubMed: 33488973DOI: 10.1021/acsmedchemlett.0c00572 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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