7D2Z

Structure of sybody SR31 in complex with the SARS-CoV-2 S Receptor Binding domain (RBD)

Summary for 7D2Z

• Entry DOI: 10.2210/pdb7d2z/pdb
• Descriptor: SR31 against SARS-CoV-2 RBD, non neutralizing, Spike protein S1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: coronavirus, covid-19, nanobody, neutralizing antibody, receptor binding protein, sars-cov-2, s protein, synthetic antibody, vhh., protein binding
• Biological source: synthetic construct; More
• Total number of polymer chains: 2
• Total formula weight: 41850.08

Authors

Li, T.,Cai, H.,Yao, H.,Qin, W.,Li, D. (deposition date: 2020-09-17, release date: 2021-02-17, Last modification date: 2023-11-29)

• Primary citation: Yao, H.,Cai, H.,Li, T.,Zhou, B.,Qin, W.,Lavillette, D.,Li, D.; A high-affinity RBD-targeting nanobody improves fusion partner's potency against SARS-CoV-2.; Plos Pathog., 17:e1009328-e1009328, 2021; PubMed: 33657135; DOI: 10.1371/journal.ppat.1009328

Experimental method

X-RAY DIFFRACTION (1.97 Å)