7CLD
Crystal structure of T2R-TTL-Cevipabulin complex
Summary for 7CLD
Entry DOI | 10.2210/pdb7cld/pdb |
Descriptor | Tubulin alpha-1B chain, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | tubulin inhibitor, tublin, structural protein |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 6 |
Total formula weight | 265349.88 |
Authors | Chen, L.J.,Chen, Q.,Yu, Y.,Yang, J.H. (deposition date: 2020-07-20, release date: 2021-07-07, Last modification date: 2023-11-29) |
Primary citation | Yang, J.,Yu, Y.,Li, Y.,Yan, W.,Ye, H.,Niu, L.,Tang, M.,Wang, Z.,Yang, Z.,Pei, H.,Wei, H.,Zhao, M.,Wen, J.,Yang, L.,Ouyang, L.,Wei, Y.,Chen, Q.,Li, W.,Chen, L. Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect. Sci Adv, 7:-, 2021 Cited by PubMed: 34138737DOI: 10.1126/sciadv.abg4168 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.611 Å) |
Structure validation
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